Order NO. C650048
小鼠抗CD19单克隆抗体
| 英文名 | Anti-CD19 mouse monoclonal antibody | ||
| 相关类别 | IVD抗体原料 | 储存 | 冷冻（-20℃） 参照组件的存储要求 |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| C650048-0100 | 100UG | 预计7日内发货 |
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| C650048-0500 | 500UG | 预计7日内发货 |
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产品描述
应用
immunohistochemistry：anti-CD19 mouse monoclonal antibody.human tonsil tissue and vermiform appendix tissue .
组分
1 mg/ml
适用样本
Human
属性
| Background | This gene encodes a member of the immunoglobulin gene superfamily. Expression of this cell surface protein is restricted to B cell lymphocytes. This protein is a reliable marker for pre-B cells but its expression diminishes during terminal B cell differentiation in antibody secreting plasma cells. The protein has two N-terminal extracellular Ig-like domains separated by a non-Ig-like domain, a hydrophobic transmembrane domain, and a large C-terminal cytoplasmic domain. This protein forms a complex with several membrane proteins including complement receptor type 2 (CD21) and tetraspanin (CD81) and this complex reduces the threshold for antigen-initiated B cell activation. Activation of this B-cell antigen receptor complex activates the phosphatidylinositol 3-kinase signalling pathway and the subsequent release of intracellular stores of calcium ions. This protein is a target of chimeric antigen receptor (CAR) T-cells used in the treatment of lymphoblastic leukemia. Mutations in this gene are associated with the disease common variable immunodeficiency 3 (CVID3) which results in a failure of B-cell differentiation and impaired secretion of immunoglobulins. CVID3 is characterized by hypogammaglobulinemia, an inability to mount an antibody response to antigen, and recurrent bacterial infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| Product name | Anti-CD19 mouse monoclonal antibody |
| Description | Mouse monoclonal antibody to CD19 |
| Host species | Mouse |
| Tested applications | IHC |
| Reactivity | Human |
| Immunogen | Recombinant protein. The exact sequence is proprietary. |
| Clone number | SG200265r |
| Isotype | / |
| Purification | Protein A/G affinity column |
| Uniprot ID | P15391 |
相关文档
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Sample Application
