Order NO. D262371
产品描述
概述
TRIM71 is the mammalian ortholog to the C. elegans heterochronic protein Lin41, a protein that is thought to be important in postembryonic development , and is genetically and biochemically downstream of both Shh and Fgf signaling pathways. Similar to its C. elegans homolog, TRIM71 is a target of the microRNA let-7 and is likely to play a role in mammalian development. Recent experiments have indicated that TRIM71 is an E3 ubiquitin ligase and can interact with the Dicer and the Argonaute proteins Ago1, Ago2, and Ago4. Overexpression and depletion of TRIM71 led to inverse changes in Ago2 protein levels, suggesting TRIM71 can regulate Ago2 turnover. Finally, TRIM71 cooperates with the pluripotency factor Lin-28 in regulating let-7. May be involved in controlling the timing of organ formation during development.
应用
酶联免疫吸附测定（ELISA），免疫组织化学（IHC）
属性
| 保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
Q2Q1W2
|
| 靶点基因 ID |
131405
|
| 靶点全称 |
tripartite motif containing 71, E3 ubiquitin protein ligase
|
| 靶点别名 |
LIN41; LIN-41
|
| 靶点研究领域 |
Epigenetics and Nuclear Signaling
|
| 亚型 |
Immunogen-specific rabbit IgG
|
