Order NO. D260481
产品描述
概述
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
应用
酶联免疫吸附测定(ELISA),免疫印迹(WB)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
O15379
|
靶点基因 ID |
8841
|
靶点全称 |
histone deacetylase 3
|
靶点别名 |
HD3; RPD3; RPD3-2
|
靶点研究领域 |
Epigenetics and Nuclear Signaling, Cancer, Metabolism, Cardiovascular, Signal Transduction
|
亚型 |
Immunogen-specific rabbit IgG
|