Order NO. D145224
人CFB重组蛋白（hFc tag C-Terminus）
| 英文名 | Human CFB Recombinant protein (hFc tag C-Terminus) | ||
| 别名 | complement factor B; BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14 | ||
| 相关类别 | 抗原 | 储存 | 冷冻（-20℃） |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D145224-0010 | 10 UG | 预计5日内发货 |
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| D145224-0050 | 50 UG | 预计5日内发货 |
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| D145224-0100 | 100 UG | 预计5日内发货 |
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产品描述
概述
Fusion protein corresponding to a region derived from 26-764 amino acids of Human CFB
属性
| Full name: | complement factor B |
| Synonyms: | BF; FB; BFD; GBG; CFAB; CFBD; PBF2; AHUS4; FBI12; H2-Bf; ARMD14 |
| Swissprot: | P00751 |
| Purity: | >95%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | HEK293 |
| Tags: | hFc tag C-Terminus |
| Species: | Human |
| Molecular mass: | The protein has a predicted molecular weight of 109.2 kDa after removal of the signal peptide. The apparent molecular weight of CFB-hFc is approximately 100-130 kDa due to glycosylation. |
| Research areas: | Immunology |
| Background: | This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. |
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