Order NO. D120535
产品描述
概述
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
应用
酶联免疫吸附测定(ELISA),免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
O14798
|
靶点基因 ID |
8794
|
靶点全称 |
tumor necrosis factor receptor superfamily member 10c
|
靶点别名 |
LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
|
靶点研究领域 |
Cancer, Immunology
|
亚型 |
Immunogen-specific rabbit IgG
|