Order NO. C650012
小鼠抗P53单克隆抗体
| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| C650012-0100 | 100UG | 预计7日内发货 |
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| C650012-0500 | 500UG | 预计7日内发货 |
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产品描述
应用
immunohistochemistry：anti-P53 mouse monoclonal antibody
组分
1 mg/ml
适用样本
Human
属性
| Background | This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. |
| Product name | Anti-P53 mouse monoclonal antibody |
| Description | Mouse monoclonal antibody to P53 |
| Host species | Mouse |
| Tested applications | ELISA, IHC-P |
| Reactivity | Human |
| Immunogen | Recombinant protein. The exact sequence is proprietary. |
| Clone number | 4G5 |
| Isotype | IgG1 |
| Purification | Protein A/G affinity purification |
| Uniprot ID | P04637 |
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