Order NO. C600317
产品描述
概述
Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53 % sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes -cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA sequence encoding the 39 amino acid of Exendin-4.
使用说明
This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
属性
Physical Appearance |
Sterile Filtered White lyophilized (freeze-dried) powder.
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Purity |
> 96 % by SDS-PAGE and HPLC analyses.
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Source |
Escherichia coli.
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Biological Activity |
1. Regulates Glucose levels rapidly; 2. Reduces Insulin resistance; 3. Reduces Glucagon; 4. Reduces HbA1c; 5. Stimulates beta cell growth which stimulates insulin production.
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Formulation |
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.
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Endotoxin |
Less than 10 EU/mg of rExendin-4 as determined by LAL method.
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Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
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AA Sequence |
HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS
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