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Order NO. C100218
英文名 Iodoacetyl LC Biotin
别名 N-Iodoacetyl-N-biotinylhexylenediamine
相关类别 生物素标记试剂 储存 冷藏(2-8℃)
分子量 510.4 N-碘代乙酸基-N-生物素己二胺
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
C100218-0050 50 MG 现货


Iodoacetyl-LC-Biotin is long-chain, sulfhydryl-reactive biotinylation reagents.For the reagent,reaction of the iodoacety1 group with a sulfhydryl (-SH) group is rapid and specific, especially when only a slight reagent-to-sulfhydrylmolar excess is used and the reaction is performed at pH 8.3 (7.5-8.5).1-3 The reaction occurs by nucleophilic substitution of iodine with a thiol (sulfhydryl) group, resulting in a stable thioether bond (Figure 1). If thiols are unavailable on the molecule, reaction can occur with histidy1 side chains at pH 6.9-7.0, but the reaction must be allowed to proceed for at least one week. Iodoacetyl reagents also will react with amino groups at pH > 10.


Iodoacetyl-LC-Biotin is not soluble in water and must be dissolved in an organic solvent such as DMF before further dilution in aqueous solutions.


50 mg/bottle


Formula C18H31IN4O3S
Net Mass Addition 382.53
Spacer arm 27.1
Purity >95% on TLC
Solubility > 2 mg/ml in DMF for subsequent dilution in water or buffer
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