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Order NO. D624518
CEP57抗原(重组蛋白)
英文名 CEP57 Antigen (Recombinant Protein)
别名 MVA2; PIG8; TSP57
相关类别 抗原 储存 冷冻(-20℃)
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D624518-0001 1 MG 预计30日内发货
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D624518-0100 100 UG 预计30日内发货
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产品描述

概述

Full length fusion protein

技术规格

Full name: centrosomal protein 57
Synonyms: MVA2; PIG8; TSP57
Swissprot: Q86XR8
Gene Accession: BC039711
Purity: >85%, as determined by Coomassie blue stained SDS-PAGE
Expression system: Escherichia coli
Tags: His tag C-Terminus, GST tag N-Terminus
Background: This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
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