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Order NO. D262907
英文名 Anti-SPAM1 rabbit polyclonal antibody
别名 HYA1; PH20; HYAL1; HYAL3; HYAL5; PH-20; SPAG15; HEL-S-96n
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human
标记物 Unconjugate 克隆类型 Unconjugate
抗原 SPAM1    
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D262907-0025 25 ul 现货
D262907-0100 100 ul 现货
D262907-0200 200 ul 现货


Background: Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications: ELISA, IHC
Name of antibody: SPAM1
Immunogen: Synthetic peptide of human SPAM1
Full name: sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
Synonyms: HYA1; PH20; HYAL1; HYAL3; HYAL5; PH-20; SPAG15; HEL-S-96n
SwissProt: P38567
ELISA Recommended dilution: 5000-10000
IHC positive control: Human tonsil
IHC Recommend dilution: 25-100
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using D262907(SPAM1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)

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