Order NO. D220518
产品描述
概述
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
应用
酶联免疫吸附测定（ELISA），免疫印迹（WB），免疫组织化学（IHC）
属性
| 保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
P04798
|
| 靶点基因 ID |
1543
|
| 靶点全称 |
cytochrome P450 family 1 subfamily A member 1
|
| 靶点别名 |
AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX
|
| 靶点研究领域 |
Metabolism, Cancer, Cardiovascular
|
| 亚型 |
Immunogen-specific rabbit IgG
|
