Order NO. D151335
产品描述
概述
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
应用
免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q96J02
|
靶点基因 ID |
83737
|
靶点全称 |
itchy E3 ubiquitin protein ligase
|
靶点别名 |
AIF4; AIP4; ADMFD; NAPP1; dJ468O1.1
|
靶点研究领域 |
Cell Biology
|
亚型 |
Immunogen-specific rabbit IgG
|