Order NO. D123957
产品描述
概述
NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.
应用
酶联免疫吸附测定(ELISA),免疫印迹(WB),免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q96MF7
|
靶点基因 ID |
286053
|
靶点全称 |
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
|
靶点别名 |
NSE2; MMS21; ZMIZ7; C8orf36
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靶点研究领域 |
Epigenetics and Nuclear Signaling, Cell Biology
|
亚型 |
Immunogen-specific rabbit IgG
|