Order NO. C640020
产品描述
概述
Human Galectin-1 also named BHL, Galaptin, GBP, L- 14 and LGALS1, is belonging to the galectins family and it is encoded by the LGALS1 gene in human. Galectin-1 is expressed by the endometrial stromal cells throughout the menstrual cycle. Galectin-1 contains a single carbohydrate recognition domain through which it can bind glycans both as a monomer and as a homodimer. Dimers are non-covenantly bound and will spontaneou sly disassociate in low concentration. Galectin -1 may act as an autocrine negative growth factor that regulates cell proliferation. Galectin - 1 is thought to play a role in the immunosuppression required for a successful pregnancy. Human Galectin-1 shares 88 %-90 % amino acid sequence identity with rat and mouse.
使用说明
This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
属性
Physical Appearance |
Sterile Filtered White lyophilized (freeze- dried) powder.
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Purity |
> 95 % by SDS-PAGE and HPLC analyses.
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Source |
Escherichia coli.
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Biological Activity |
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human blood monocytes is in a concentration range of 1.0-10 ng/ml.
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Formulation |
Lyophilized from a 0.2 μ m filtered solution in PBS,pH 7.4,with 1 mM DTT.
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Endotoxin |
Less than 0.1 EU/ μg of rHuGalectin -1 as determined by LAL method.
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Reconstitution |
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentrati on of 0.1 - 1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 °C. Further dilutions should be made in appropriate buffered solutions.
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AA Sequence |
ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD
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