重组猕猴IL-4Ra, C-6His, Human Cells,Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha , C-6His, Human Cells 生命科学产品与技术服务-生工生物工程(上海)股份有限公司

Order NO. C522354

重组猕猴IL-4Ra, C-6His, Human Cells

英文名	Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha , C-6His, Human Cells
相关类别	其他重组蛋白	储存	冷冻（-20℃）

编号	包装	库存	目录价（￥）	您的价格（￥）	数量
C522354-0010	10 UG	预计10日内发货
C522354-0050	50 UG	预计10日内发货

产品描述

概述

Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Met26-Arg232 is expressed with a 6His tag at the C-terminus.

使用说明

This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.

属性

Tag	C-6His
种属	Cynomolgus
表达系统	Human Cells
Accession#	G7Q0S7
Source	Human Cells
Formulation_Description	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution	Dissolve the lyophilized protein in distilled water.
Purity	Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin	Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Background	Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.