Order NO. C522349
产品描述
概述
Recombinant Human Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B is produced by our Mammalian expression system and the target gene encoding Gly17-Gln208 is expressed with a 6His tag at the C-terminus.
使用说明
This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
属性
Tag |
C-6His
|
种属 |
Human
|
表达系统 |
Human Cells
|
Accession# |
O75015
|
Source |
Human Cells
|
Formulation_Description |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
|
Storage |
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
|
Reconstitution |
Dissolve the lyophilized protein in distilled water.
|
Purity |
Greater than 95% as determined by reducing SDS-PAGE.
|
Endotoxin |
Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
|
Background |
Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activation. FCGR3B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
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