重组人CD170, C-6His-Flag-Fc, Human Cells,Recombinant Human Sialic Acid-binding Ig-like Lectin 5 , C-6His-Flag-Fc, Human Cells 生命科学产品与技术服务-生工生物工程(上海)股份有限公司

Order NO. C522343

重组人CD170, C-6His-Flag-Fc, Human Cells

英文名	Recombinant Human Sialic Acid-binding Ig-like Lectin 5 , C-6His-Flag-Fc, Human Cells
相关类别	其他重组蛋白	储存	冷冻（-20℃）

编号	包装	库存	目录价（￥）	您的价格（￥）	数量
C522343-0010	10 UG	预计10日内发货
C522343-0050	50 UG	预计10日内发货

产品描述

概述

Recombinant Human Sialic Acid-binding Ig-like Lectin 5 is produced by our Mammalian expression system and the target gene encoding Glu17-Thr434 is expressed with a 6His, Flag tag,Fc tag at the C-terminus.

使用说明

This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.

属性

Tag	C-6His-Flag-Fc
种属	Human
表达系统	Human Cells
Accession#	O15389
Source	Human Cells
Formulation_Description	Lyophilized from a 0.2 μm filtered solution of 20mM PB,150 mM NaCl,pH8.0.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution	Dissolve the lyophilized protein in distilled water.
Purity	Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin	Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Background	Human Siglec-5 are Itype(Igtype) lectins belonging to the Ig superfamily,They are characterized by an N terminal Ig-like V type domain which mediates sialic acid binding, followed by varying numbers of Ig-like C2 type domains. SIGLEC5 has also been designated CD170, they are expressed by monocytic or myeloid lineage cells, and also found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. SIGLEC5 are expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. One remarkable feature of the CD33 related Siglecs is their differential expression pattern within the hematopoietic system This fact, together with the presence of two conserved immunoreceptor tyrosinebased inhibition motifs (ITIMs) in their cytoplasma tails, suggests that CD33 related Siglecs are involved in the regulation of cellular activation within the immune system.