Order NO. C520508
产品描述
概述
Recombinant Human Cadherin-3 is produced by our Mammalian expression system and the target gene encoding Glu25-Gly654(Val237Met) is expressed with a 6His tag at the C-terminus.
使用说明
This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
属性
Taq |
C-6His
|
种属 |
Human
|
表达系统 |
Human Cells
|
Accession# |
P22223
|
Source |
Human Cells
|
Formulation_Description |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
|
Storage |
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
|
Reconstitution |
Dissolve the lyophilized protein in distilled water.
|
Purity |
Greater than 85% as determined by reducing SDS-PAGE.
|
Endotoxin |
Less than 0.1 ng/?g (1 EU/?g) as determined by LAL test.
|
Background |
Cadherin-3 (CDH3) is a single-pass type I membrane protein that belongs to the cadherin superfamily. CDH3 is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. CDH3 is expressed in some normal epithelial tissues and in some carcinoma cell lines. CDH3 preferentially interacts with themselves in a homophilic manner in connecting cells. CDH3 is involved in loss of heterozygosity events in breast and prostate cancer. Mutations in CDH3 have been associated with congential hypotrichosis with juvenile macular dystrophy.
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