重组人CDH1, C-6His, Human Cells,Recombinant Human Cadherin-1/E-Cadherin/CDH1 , C-6His, Human Cells 生命科学产品与技术服务-生工生物工程(上海)股份有限公司

Order NO. C520504

重组人CDH1, C-6His, Human Cells

英文名	Recombinant Human Cadherin-1/E-Cadherin/CDH1 , C-6His, Human Cells
相关类别	其他重组蛋白	储存	冷冻（-20℃）

编号	包装	库存	目录价（￥）	您的价格（￥）	数量
C520504-0010	10 UG	预计10日内发货
C520504-0050	50 UG	预计10日内发货

产品描述

概述

Recombinant Human Cadherin-1/E-Cadherin/CDH1 is produced by our Mammalian expression system and the target gene encoding Asp155-Ile707 is expressed with a 6His tag at the C-terminus.

使用说明

This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.

属性

Tag	C-6His
种属	Human
表达系统	Human Cells
Accession#	P12830
Source	Human Cells
Formulation_Description	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution	Dissolve the lyophilized protein in distilled water.
Purity	Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin	Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Background	E-Cadherin is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Also, E-Cadherin has a potent invasive suppressor role and it is a ligand for integrin alpha-E/beta-7.