重组人CD272, C-Fc, Human cells,Recombinant Human B- and T-Lymphocyte Attenuator , C-Fc, Human cells 生命科学产品与技术服务-生工生物工程(上海)股份有限公司

Order NO. C520487

重组人CD272, C-Fc, Human cells

英文名	Recombinant Human B- and T-Lymphocyte Attenuator , C-Fc, Human cells
相关类别	其他重组蛋白	储存	冷冻（-20℃）

编号	包装	库存	目录价（￥）	您的价格（￥）	数量
C520487-0010	10 UG	预计10日内发货
C520487-0050	50 UG	预计10日内发货

产品描述

概述

Recombinant Human B- and T-Lymphocyte Attenuator is produced by our Mammalian expression system and the target gene encoding Lys31-Leu150 is expressed with a Fc tag at the C-terminus.

使用说明

This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.

属性

Tag	C-Fc
种属	Human
表达系统	Human cells
Accession#	Q7Z6A9-2
Source	Human Cells
Formulation_Description	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Reconstitution	Dissolve the lyophilized protein in distilled water.
Purity	Greater than 90% as determined by reducing SDS-PAGE.
Endotoxin	Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Background	B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.